Description

Claudin-18, (CLDN18). Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. The isoform CLDN18.2 is considered of particular importance as a CART target.


Clinical trials

NCT04404595 - Pancreatic Cancer
NCT03159819 - Pancreatic Cancer


Target gene expression

The following plot describes the expression, in different tissues and TCGA cancers, of the different isoforms of the gene CLDN18.


Target essentiality


Protein properties

The following plot describes the target topology, highlighting the position of the endo-, ecto- and transmembrane domains, as well as the position of a signal peptide, when present. The last three rows describe the position of potential epitopes, as well as phosphorylation and glycosylation sites.