Claudin-18, (CLDN18). Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. The isoform CLDN18.2 is considered of particular importance as a CART target.
NCT04404595 -
Pancreatic Cancer
NCT03159819 -
Pancreatic Cancer
The following plot describes the target topology, highlighting the
position of the endo-, ecto- and transmembrane domains, as well as the
position of a signal peptide, when present. The last three rows describe
the position of potential epitopes, as well as phosphorylation and
glycosylation sites.